Version 5.4
Homo sapiens Gene: GUCA2B
Summary
InnateDB Gene IDBG-97167.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GUCA2B
Gene Name guanylate cyclase activator 2B (uroguanylin)
Synonyms GCAP-II; UGN
Species Homo sapiens
Ensembl Gene ENSG00000044012
Encoded Proteins
IDBP-97169
guanylate cyclase activator 2B (uroguanylin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the guanylin family, and is expressed in the stomach and intestine. This protein functions as an endogenous ligand for the guanylate cyclase-C receptor and stimulates an increase in cyclic GMP, a key component of several intracellular signal transduction pathways. It maybe involved in salt and water secretion into the intestinal lumen as well as the renal tubules, and thus regulate electrolyte homeostasis in these tissues. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:42153421-42155824
Strand Forward strand
Band p34.2
Transcripts
ENST00000372581 ENSP00000361662
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008048 calcium sensitive guanylate cyclase activator activity
GO:0030250 guanylate cyclase activator activity
Biological Process
GO:0006182 cGMP biosynthetic process
GO:0007588 excretion
GO:0007589 body fluid secretion
GO:0030802 regulation of cyclic nucleotide biosynthetic process
GO:0031284 positive regulation of guanylate cyclase activity
GO:0045776 negative regulation of blood pressure
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032978
View Gene Order
ENSBTAG00000007194
Not yet available
Cross-References
SwissProt Q16661
TrEMBL
UniProt Splice Variant
Entrez Gene 2981
UniGene Hs.32966
RefSeq NM_007102
HUGO HGNC:4683
OMIM 601271
CCDS CCDS464
HPRD 03170
IMGT
EMBL BC069301 BC093779 BC093781 U34279 U55058 Z50753 Z70295
GenPept AAC50416 AAC51729 AAH69301 AAH93779 AAH93781 CAA90629 CAA94311
RNA Seq Atlas 2981

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca