Version 5.4
Homo sapiens Protein: VTA1
Summary
InnateDB Protein IDBP-97192.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VTA1
Protein Name Vps20-associated 1 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000356602
InnateDB Gene IDBG-97190 (VTA1)
Protein Structure
UniProt Annotation
Function Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding. {ECO:0000250, ECO:0000269PubMed:15644320}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:15644320}. Endosome membrane {ECO:0000305PubMed:15644320}; Peripheral membrane protein {ECO:0000305PubMed:15644320}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0015031 protein transport
GO:0016032 viral process
GO:0016197 endosomal transport
GO:0019058 viral life cycle
GO:0061024 membrane organization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NP79
PhosphoSite PhosphoSite-Q9NP79
TrEMBL
UniProt Splice Variant
Entrez Gene 51534
UniGene Hs.623074
RefSeq NP_057569
HUGO HGNC:20954
OMIM 610902
CCDS CCDS5197
HPRD 09855
IMGT
EMBL AF060225 AF151062 AF271994 AK000051 AL033522 AL136684 BC005937 BC006989 BC022536 CH471051 CR457207
GenPept AAF36148 AAF76210 AAG43125 AAH05937 AAH06989 AAH22536 BAA90909 CAB66619 CAG33488 CAI21072 EAW47883 EAW47885

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca