Version 5.4
Homo sapiens Protein: HIVEP2
Summary
InnateDB Protein IDBP-97265.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIVEP2
Protein Name human immunodeficiency virus type I enhancer binding protein 2
Synonyms HIV-EP2; MBP-2; MIBP1; SHN2; ZAS2; ZNF40B;
Species Homo sapiens
Ensembl Protein ENSP00000356575
InnateDB Gene IDBG-97259 (HIVEP2)
Protein Structure
UniProt Annotation
Function This protein specifically binds to the DNA sequence 5'- GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon- beta genes. It may act in T-cell activation.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Expressed in brain and skeletal muscle. {ECO:0000269PubMed:10207097}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
IPR022755 Zinc finger, double-stranded RNA binding
PFAM PF00096
PF12171
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P31629
PhosphoSite PhosphoSite-P31629
TrEMBL B4DKE9
UniProt Splice Variant
Entrez Gene 3097
UniGene Hs.510172
RefSeq NP_006725
HUGO HGNC:4921
OMIM 143054
CCDS CCDS43510
HPRD 00881
IMGT
EMBL AF153836 AK296531 AL023584 M60119 M61744 X65644
GenPept AAA36202 AAB88218 AAF81365 BAG59161 CAA19042 CAA46596

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca