InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDC20

Summary

InnateDB Protein

IDBP-97416.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC20

Protein Name

cell division cycle 20 homolog (S. cerevisiae)

Synonyms

bA276H19.3; CDC20A; p55CDC;

Species

Homo sapiens

Ensembl Protein

ENSP00000361540

InnateDB Gene

IDBG-97410 (CDC20)

Protein Structure

UniProt Annotation

Function

Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. {ECO:0000269PubMed:9637688, ECO:0000269PubMed:9734353, ECO:0000269PubMed:9811605}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:20034488}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269PubMed:20034488}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 210 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	210 [view]
Protein-Protein	207 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019899	enzyme binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0007049	cell cycle
GO:0007067	mitotic nuclear division
GO:0007094	mitotic spindle assembly checkpoint
GO:0008284	positive regulation of cell proliferation
GO:0016567	protein ubiquitination
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031915	positive regulation of synaptic plasticity
GO:0040020	regulation of meiosis
GO:0050773	regulation of dendrite development
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051488	activation of anaphase-promoting complex activity
GO:0090129	positive regulation of synapse maturation

Cellular Component

GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005680	anaphase-promoting complex
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm