InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDC20

Summary

InnateDB Gene

IDBG-97410.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC20

Gene Name

cell division cycle 20 homolog (S. cerevisiae)

Synonyms

bA276H19.3; CDC20A; p55CDC

Species

Homo sapiens

Ensembl Gene

ENSG00000117399

Encoded Proteins

IDBP-97414

cell division cycle 20 homolog (S. cerevisiae)

IDBP-97416

cell division cycle 20 homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008]
CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:43358955-43363203

Strand

Forward strand

Band

p34.2

Transcripts

ENST00000310955	ENSP00000308450
ENST00000372462	ENSP00000361540
ENST00000478882
ENST00000482046

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 210 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	210 [view]
Protein-Protein	207 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019899	enzyme binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0007049	cell cycle
GO:0007067	mitotic nuclear division
GO:0007094	mitotic spindle assembly checkpoint
GO:0008284	positive regulation of cell proliferation
GO:0016567	protein ubiquitination
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031915	positive regulation of synaptic plasticity
GO:0040020	regulation of meiosis
GO:0050773	regulation of dendrite development
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051488	activation of anaphase-promoting complex activity
GO:0090129	positive regulation of synapse maturation

Cellular Component

GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005680	anaphase-promoting complex
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm