Version 5.4
Homo sapiens Protein: NPW
Summary
InnateDB Protein IDBP-9753.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPW
Protein Name neuropeptide W
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000330070
InnateDB Gene IDBG-9751 (NPW)
Protein Structure
UniProt Annotation
Function Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30. {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Detected at high levels in the substantia nigra, fetal kidney and trachea; at lower levels in testis, uterus, ovary and placenta. Not detectable in many regions of the central nervous system. Also detected at high levels in lymphoblastic leukemia and colorectal adenocarcinoma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007631 feeding behavior
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR013297 Neuropeptide B/W precursor family
IPR013299 Neuropeptide W precursor
PFAM PF15180
PRINTS PR01888
PR01890
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N729
PhosphoSite PhosphoSite-
TrEMBL H3BT17
UniProt Splice Variant
Entrez Gene 283869
UniGene
RefSeq NP_001092926
HUGO HGNC:30509
OMIM 607997
CCDS CCDS42102
HPRD
IMGT
EMBL AB084276 AC005606
GenPept BAC07172

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca