Homo sapiens Gene: NPW
Summary
InnateDB Gene IDBG-9751.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPW
Gene Name neuropeptide W
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183971
Encoded Proteins
neuropeptide W
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:2009926-2020755
Strand Forward strand
Band p13.3
Transcripts
ENST00000329610 ENSP00000330070
ENST00000567649 ENSP00000457009
ENST00000566435 ENSP00000456974
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007631 feeding behavior
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
G alpha (i) signalling events pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H3BT17
UniProt Splice Variant
Entrez Gene 283869
UniGene
RefSeq NM_001099456
HUGO HGNC:30509
OMIM 607997
CCDS CCDS42102
HPRD
IMGT
EMBL AC005606
GenPept
RNA Seq Atlas 283869