InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP6V1B2

Summary

InnateDB Protein

IDBP-9759.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V1B2

Protein Name

ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2

Synonyms

ATP6B1B2; ATP6B2; HO57; VATB; Vma2; VPP3;

Species

Homo sapiens

Ensembl Protein

ENSP00000276390

InnateDB Gene

IDBG-9757 (ATP6V1B2)

Protein Structure

UniProt Annotation

Function

Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Subcellular Localization

Endomembrane system; Peripheral membrane protein. Melanosome. Note=Endomembrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.

Experimentally validated
Total	69 [view]
Protein-Protein	69 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0046961	proton-transporting ATPase activity, rotational mechanism

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0008286	insulin receptor signaling pathway
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0033572	transferrin transport
GO:0046034	ATP metabolic process
GO:0051701	interaction with host
GO:0055085	transmembrane transport
GO:0090382	phagosome maturation

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0012505	endomembrane system
GO:0016021	integral component of membrane
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain
GO:0033180	proton-transporting V-type ATPase, V1 domain
GO:0042470	melanosome
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
IPR000793 ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal
IPR004100 ATPase, F1 complex alpha/beta subunit, N-terminal domain
IPR005723 ATPase, V1 complex, subunit B
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00006
PF00306
PF02874

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P21281

PhosphoSite