Version 5.4
Homo sapiens Gene: ATP6V1B2
Summary
InnateDB Gene IDBG-9757.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP6V1B2
Gene Name ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
Synonyms ATP6B1B2; ATP6B2; HO57; VATB; Vma2; VPP3
Species Homo sapiens
Ensembl Gene ENSG00000147416
Encoded Proteins
IDBP-9759
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
IDBP-481024
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
IDBP-475839
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
IDBP-474135
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
IDBP-484593
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:20197367-20226819
Strand Forward strand
Band p21.3
Transcripts
ENST00000276390 ENSP00000276390
ENST00000523482
ENST00000523478 ENSP00000430154
ENST00000520830 ENSP00000428069
ENST00000519667 ENSP00000430682
ENST00000521442 ENSP00000430866
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
Experimentally validated
Total 69 [view]
Protein-Protein 69 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0015078 hydrogen ion transmembrane transporter activity
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0006879 cellular iron ion homeostasis
GO:0008286 insulin receptor signaling pathway
GO:0015991 ATP hydrolysis coupled proton transport
GO:0015992 proton transport
GO:0033572 transferrin transport
GO:0046034 ATP metabolic process
GO:0051701 interaction with host
GO:0055085 transmembrane transport
GO:0090382 phagosome maturation
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0012505 endomembrane system
GO:0016021 integral component of membrane
GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain
GO:0033180 proton-transporting V-type ATPase, V1 domain
GO:0042470 melanosome
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006273
View Gene Order
ENSBTAG00000018646
Not yet available
Pathways
NETPATH
REACTOME
REACT_25283
Transferrin endocytosis and recycling pathway
REACT_25060
Iron uptake and transport pathway
REACT_1109
Insulin receptor recycling pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_121256
Phagosomal maturation (early endosomal stage) pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_111102
Signal Transduction pathway
REACT_121237
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
REACT_116125
Disease pathway
KEGG
hsa05110
Vibrio cholerae infection pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa00190
Oxidative phosphorylation pathway
hsa04966
Collecting duct acid secretion pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 526
UniGene Hs.295917
RefSeq NM_001693
HUGO HGNC:854
OMIM 606939
CCDS CCDS6014
HPRD 06088
IMGT
EMBL
GenPept
RNA Seq Atlas 526

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca