Version 5.4
Homo sapiens Protein: DPH2
Summary
InnateDB Protein IDBP-97617.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPH2
Protein Name DPH2 homolog (S. cerevisiae)
Synonyms DPH2L2;
Species Homo sapiens
Ensembl Protein ENSP00000255108
InnateDB Gene IDBG-97615 (DPH2)
Protein Structure
UniProt Annotation
Function Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Strongly expressed in skeletal muscle. Moderately expressed in heart, small intestine, liver, pancreas, testis and colon. Weakly expressed in brain, placenta, kidney, spleen, thymus, prostate, ovary and lymphocytes. {ECO:0000269PubMed:9782084}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002728 Diphthamide synthesis, DPH1/DPH2
IPR010014 Diphthamide synthesis DHP2, eukaryotic
PFAM PF01866
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BQC3
PhosphoSite PhosphoSite-Q9BQC3
TrEMBL B3KRB8
UniProt Splice Variant
Entrez Gene 1802
UniGene Hs.632398
RefSeq NP_001375
HUGO HGNC:3004
OMIM 603456
CCDS CCDS504
HPRD 16023
IMGT
EMBL AF053003 AK091303 AK315506 AL357079 BC001389 BC003181 BC016956 BT007431 CH471059
GenPept AAC18086 AAH01389 AAH03181 AAH16956 AAP36099 BAG37890 BAG52330 CAI16800 EAX07070 EAX07071

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca