InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STXBP5

Summary

InnateDB Protein

IDBP-97622.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STXBP5

Protein Name

syntaxin binding protein 5 (tomosyn)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000356450

InnateDB Gene

IDBG-97618 (STXBP5)

Protein Structure

UniProt Annotation

Function

Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Cytoplasmic, and associated with vesicular membranes and the plasma membrane. Detected at synapses and on synaptic vesicles (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017075	syntaxin-1 binding

Biological Process

GO:0010468	regulation of gene expression
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0030193	regulation of blood coagulation
GO:0045921	positive regulation of exocytosis

Cellular Component

GO:0005737	cytoplasm
GO:0005892	acetylcholine-gated channel complex
GO:0008021	synaptic vesicle
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030659	cytoplasmic vesicle membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000664 Lethal(2) giant larvae protein
IPR001388 Synaptobrevin
IPR001680 WD40 repeat
IPR013577 Lethal giant larvae homologue 2
IPR013905 Lethal giant larvae (Lgl)-like, C-terminal domain
IPR017986 WD40-repeat-containing domain

PFAM

PF00957
PF00400
PF08366
PF08596

PRINTS

PR00962
PR00219

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt