Version 5.4
Homo sapiens Protein: SLC6A9
Summary
InnateDB Protein IDBP-97661.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC6A9
Protein Name solute carrier family 6 (neurotransmitter transporter, glycine), member 9
Synonyms GLYT1;
Species Homo sapiens
Ensembl Protein ENSP00000350362
InnateDB Gene IDBG-97649 (SLC6A9)
Protein Structure
UniProt Annotation
Function Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Isoform GlyT-1A and isoform GlyT-1B can be found in brain, kidney, pancreas, lung, placenta and liver but isoform GlyT-1C is only found in brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005283 sodium:amino acid symporter activity
GO:0005328 neurotransmitter:sodium symporter activity
GO:0015375 glycine:sodium symporter activity
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006810 transport
GO:0006836 neurotransmitter transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000175 Sodium:neurotransmitter symporter
IPR003028 Sodium:neurotransmitter symporter, glycine, type 1
PFAM PF00209
PRINTS PR00176
PR01204
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P48067
PhosphoSite PhosphoSite-P48067
TrEMBL E9PJ65
UniProt Splice Variant
Entrez Gene 6536
UniGene Hs.742306
RefSeq NP_008865
HUGO HGNC:11056
OMIM 601019
CCDS CCDS41316
HPRD 03010
IMGT
EMBL AK296438 AK298611 AL139220 CH471059 S70609 S70612
GenPept AAB30784 AAB30785 BAH12354 BAH12825 CAI19428 CAI19429 CAI19430 EAX07056 EAX07057

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca