InnateDB Protein
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IDBP-97839.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RAET1G
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Protein Name
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retinoic acid early transcript 1G
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000356330
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InnateDB Gene
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IDBG-97837 (RAET1G)
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Protein Structure
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Function |
Acts as a ligand for the KLRK1 receptor and mediates NK cell cytotoxicity via the receptor. {ECO:0000269PubMed:15240696}.
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Subcellular Localization |
Isoform 1: Cell membrane {ECO:0000269PubMed:19223974}; Single-pass type I membrane protein {ECO:0000269PubMed:19223974}. Cell membrane {ECO:0000269PubMed:19223974}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:19223974}. Endoplasmic reticulum {ECO:0000269PubMed:19223974}. Note=Mainly found inside the cell, with a minority of the protein reaching the cell surface.Isoform 2: Secreted {ECO:0000269PubMed:19223974}.
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Disease Associations |
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Tissue Specificity |
Isoform 1 is highly expressed in colon and in a number of tumor cell lines and highly restricted in normal tissues. Both isoforms are frequently expressed in cell lines derived from epithelial cancers, and in primary breast cancers. {ECO:0000269PubMed:15240696, ECO:0000269PubMed:19223974}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0046703
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natural killer cell lectin-like receptor binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001039
MHC class I alpha chain, alpha1 alpha2 domains
IPR011162
MHC classes I/II-like antigen recognition protein
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PFAM |
PF00129
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6H3X3
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PhosphoSite |
PhosphoSite-Q6H3X3
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TrEMBL |
J7HEM2
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UniProt Splice Variant |
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Entrez Gene |
353091
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UniGene |
Hs.558792
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RefSeq |
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HUGO |
HGNC:16795
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OMIM |
609244
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CCDS |
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HPRD |
16467
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IMGT |
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EMBL |
AY172579
AY172580
JX162560
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GenPept |
AAO22238
AAO22239
AFP99104
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