Version 5.4
Homo sapiens Protein: RAET1G
Summary
InnateDB Protein IDBP-97841.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAET1G
Protein Name retinoic acid early transcript 1G
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000356329
InnateDB Gene IDBG-97837 (RAET1G)
Protein Structure
UniProt Annotation
Function Acts as a ligand for the KLRK1 receptor and mediates NK cell cytotoxicity via the receptor. {ECO:0000269PubMed:15240696}.
Subcellular Localization Isoform 1: Cell membrane {ECO:0000269PubMed:19223974}; Single-pass type I membrane protein {ECO:0000269PubMed:19223974}. Cell membrane {ECO:0000269PubMed:19223974}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:19223974}. Endoplasmic reticulum {ECO:0000269PubMed:19223974}. Note=Mainly found inside the cell, with a minority of the protein reaching the cell surface.Isoform 2: Secreted {ECO:0000269PubMed:19223974}.
Disease Associations
Tissue Specificity Isoform 1 is highly expressed in colon and in a number of tumor cell lines and highly restricted in normal tissues. Both isoforms are frequently expressed in cell lines derived from epithelial cancers, and in primary breast cancers. {ECO:0000269PubMed:15240696, ECO:0000269PubMed:19223974}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0046703 natural killer cell lectin-like receptor binding
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
GO:0042267 natural killer cell mediated cytotoxicity
Cellular Component
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031225 anchored component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
IPR011162 MHC classes I/II-like antigen recognition protein
PFAM PF00129
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6H3X3
PhosphoSite PhosphoSite-Q6H3X3
TrEMBL J7HEM2
UniProt Splice Variant
Entrez Gene 353091
UniGene Hs.558792
RefSeq NP_001001788
HUGO HGNC:16795
OMIM 609244
CCDS CCDS43514
HPRD 16467
IMGT
EMBL AY172579 AY172580 JX162560
GenPept AAO22238 AAO22239 AFP99104

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca