InnateDB Protein
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IDBP-9786.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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LZTS1
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Protein Name
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leucine zipper, putative tumor suppressor 1
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Synonyms
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F37; FEZ1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000265801
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InnateDB Gene
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IDBG-9778 (LZTS1)
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Protein Structure
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Function |
Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269PubMed:10097140, ECO:0000269PubMed:11464283, ECO:0000269PubMed:11504921}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Associated with the plasma membrane and with microtubules. Detected in dendritic spines, especially in the postsynaptic density (By similarity). {ECO:0000250}.
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Disease Associations |
Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. {ECO:0000269PubMed:10097140}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Highly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas. Not detectable in primary tumors from breast and prostate and in many cancer cell lines. {ECO:0000269PubMed:10097140}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y250
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PhosphoSite |
PhosphoSite-Q9Y250
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
11178
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UniGene |
Hs.521432
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RefSeq |
NP_066300
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HUGO |
HGNC:13861
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OMIM |
606551
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CCDS |
CCDS6015
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HPRD |
05945
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IMGT |
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EMBL |
AF123652
AF123653
AF123654
AF123655
AF123656
AF123657
AF123658
AF123659
BC075006
BC075007
CH471080
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GenPept |
AAD23833
AAD23834
AAD23835
AAD23836
AAD23837
AAD23838
AAD23839
AAD23840
AAH75006
AAH75007
EAW63753
EAW63755
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