Version 5.4
Homo sapiens Protein: PPP1R14C
Summary
InnateDB Protein IDBP-97874.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP1R14C
Protein Name protein phosphatase 1, regulatory (inhibitor) subunit 14C
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000355260
InnateDB Gene IDBG-97872 (PPP1R14C)
Protein Structure
UniProt Annotation
Function Inhibitor of the PP1 regulatory subunit PPP1CA.
Subcellular Localization Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in breast cancer. {ECO:0000269PubMed:12747765}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004865 protein serine/threonine phosphatase inhibitor activity
Biological Process
GO:0042325 regulation of phosphorylation
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR008025 PKC-activated phosphatase-1 inhibitor
PFAM PF05361
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TAE6
PhosphoSite PhosphoSite-Q8TAE6
TrEMBL
UniProt Splice Variant
Entrez Gene 81706
UniGene Hs.715251
RefSeq NP_112211
HUGO HGNC:14952
OMIM 613242
CCDS CCDS5226
HPRD 17890
IMGT
EMBL AF308297 AF407165 AF407166 AL096708 AL355497 BC015773
GenPept AAG48264 AAH15773 AAL83506 AAL83507 CAH74129 CAI19346

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca