InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IYD

Summary

InnateDB Protein

IDBP-97882.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IYD

Protein Name

iodotyrosine deiodinase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000343763

InnateDB Gene

IDBG-97878 (IYD)

Protein Structure

UniProt Annotation

Function

Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine. {ECO:0000269PubMed:15289438}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15289438}; Single-pass membrane protein {ECO:0000269PubMed:15289438}.

Disease Associations

Thyroid dyshormonogenesis 4 (TDH4) [MIM:274800]: A disorder due to thyroid dyshormonogenesis, causing severe hypothyroidism, goiter, excessive levels of iodotyrosine in serum and urine, and variable mental deficits derived from unrecognized and untreated hypothyroidism. {ECO:0000269PubMed:18434651}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed at a high level in thyroid gland and at lower level in kidney and trachea. {ECO:0000269PubMed:15289438}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016491	oxidoreductase activity

Biological Process

GO:0006590	thyroid hormone generation
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process