InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AKAP12

Summary

InnateDB Protein

IDBP-97944.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKAP12

Protein Name

A kinase (PRKA) anchor protein 12

Synonyms

AKAP250; SSeCKS;

Species

Homo sapiens

Ensembl Protein

ENSP00000352794

InnateDB Gene

IDBG-97940 (AKAP12)

Protein Structure

UniProt Annotation

Function

Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).

Subcellular Localization

Cytoplasm, cell cortex {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000305}. Note=May be part of the cortical cytoskeleton.

Disease Associations

Tissue Specificity

Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	20 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008179	adenylate cyclase binding
GO:0051018	protein kinase A binding

Biological Process

GO:0006605	protein targeting
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0010739	positive regulation of protein kinase A signaling
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0090036	regulation of protein kinase C signaling