InnateDB Protein
|
IDBP-97946.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
AKAP12
|
Protein Name
|
A kinase (PRKA) anchor protein 12
|
Synonyms
|
AKAP250; SSeCKS;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000346702
|
InnateDB Gene
|
IDBG-97940 (AKAP12)
|
Protein Structure
|
|
Function |
Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
|
Subcellular Localization |
Cytoplasm, cell cortex {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000305}. Note=May be part of the cortical cytoskeleton.
|
Disease Associations |
|
Tissue Specificity |
Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
22
[view]
|
Protein-Protein |
20
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
1
[view]
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001573
Protein kinase A anchoring, WSK motif
IPR018459
RII binding domain
|
PFAM |
PF03832
PF10522
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q02952
|
PhosphoSite |
PhosphoSite-Q02952
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
9590
|
UniGene |
Hs.711689
|
RefSeq |
NP_653080
|
HUGO |
HGNC:370
|
OMIM |
604698
|
CCDS |
CCDS5230
|
HPRD |
05263
|
IMGT |
|
EMBL |
AB003476
AB210003
AF001504
AL033392
AL356535
AL590413
CR749527
M96322
U81607
|
GenPept |
AAA35931
AAB58938
AAC51366
BAA19927
BAE06085
CAH18338
CAI13590
CAI13591
CAI16151
CAI20467
CAI20468
|
|
|