InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AKR1A1

Summary

InnateDB Protein

IDBP-97969.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKR1A1

Protein Name

aldo-keto reductase family 1, member A1 (aldehyde reductase)

Synonyms

ALDR1; ALR; ARM; DD3; HEL-S-6;

Species

Homo sapiens

Ensembl Protein

ENSP00000361140

InnateDB Gene

IDBG-97967 (AKR1A1)

Protein Structure

UniProt Annotation

Function

Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). {ECO:0000269PubMed:10510318, ECO:0000269PubMed:11306097, ECO:0000269PubMed:18276838}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung. {ECO:0000269PubMed:10510318, ECO:0000269PubMed:11306097}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004032	alditol:NADP+ 1-oxidoreductase activity
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0047939	L-glucuronate reductase activity

Biological Process

GO:0006006	glucose metabolic process
GO:0006081	cellular aldehyde metabolic process
GO:0019853	L-ascorbic acid biosynthetic process
GO:0042840	D-glucuronate catabolic process
GO:0046185	aldehyde catabolic process
GO:0055114	oxidation-reduction process