Homo sapiens Gene: AKR1A1
Summary
InnateDB Gene IDBG-97967.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKR1A1
Gene Name aldo-keto reductase family 1, member A1 (aldehyde reductase)
Synonyms ALDR1; ALR; ARM; DD3; HEL-S-6
Species Homo sapiens
Ensembl Gene ENSG00000117448
Encoded Proteins
aldo-keto reductase family 1, member A1 (aldehyde reductase)
aldo-keto reductase family 1, member A1 (aldehyde reductase)
aldo-keto reductase family 1, member A1 (aldehyde reductase)
aldo-keto reductase family 1, member A1 (aldehyde reductase)
aldo-keto reductase family 1, member A1 (aldehyde reductase)
aldo-keto reductase family 1, member A1 (aldehyde reductase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:45550543-45570049
Strand Forward strand
Band p34.1
Transcripts
ENST00000372070 ENSP00000361140
ENST00000351829 ENSP00000312606
ENST00000434299 ENSP00000398414
ENST00000496999
ENST00000476957
ENST00000481885 ENSP00000476978
ENST00000471651 ENSP00000476713
ENST00000497973
ENST00000473038
ENST00000495913
ENST00000487654
ENST00000475919
ENST00000475985
ENST00000621846 ENSP00000480713
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004032 alditol:NADP+ 1-oxidoreductase activity
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0047939 L-glucuronate reductase activity
Biological Process
GO:0006006 glucose metabolic process
GO:0006081 cellular aldehyde metabolic process
GO:0019853 L-ascorbic acid biosynthetic process
GO:0042840 D-glucuronate catabolic process
GO:0046185 aldehyde catabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0016324 apical plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
Glycolysis / Gluconeogenesis pathway
Pentose and glucuronate interconversions pathway
Glycerolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q5T621 V9GYG2 V9HWI0
UniProt Splice Variant
Entrez Gene 10327
UniGene
RefSeq NM_001202413 NM_153326 NM_001202414 NM_006066
HUGO HGNC:380
OMIM 103830
CCDS CCDS523
HPRD
IMGT
EMBL AF036680 AF036681 AF036682 AF036683 AF112484 AF112485 AK293083 AL355480 BC000670 BC005394 BT007003 CH471059 CR457010 EU668319 EU794588 J04794
GenPept AAA51711 AAB92369 AAF01260 AAH00670 AAH05394 AAP35649 ACF94472 ACJ13642 BAF85772 CAG33291 CAI22459 EAX06970 EAX06971 EAX06972 EAX06974
RNA Seq Atlas 10327