InnateDB Protein
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IDBP-97971.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AKR1A1
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Protein Name
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aldo-keto reductase family 1, member A1 (aldehyde reductase)
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Synonyms
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ALDR1; ALR; ARM; DD3; HEL-S-6;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000312606
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InnateDB Gene
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IDBG-97967 (AKR1A1)
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Protein Structure
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Function |
Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). {ECO:0000269PubMed:10510318, ECO:0000269PubMed:11306097, ECO:0000269PubMed:18276838}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung. {ECO:0000269PubMed:10510318, ECO:0000269PubMed:11306097}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR020471
Aldo/keto reductase subgroup
IPR023210
NADP-dependent oxidoreductase domain
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PFAM |
PF00248
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PRINTS |
PR00069
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PIRSF |
PIRSF000097
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P14550
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PhosphoSite |
PhosphoSite-P14550
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TrEMBL |
V9HWI0
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UniProt Splice Variant |
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Entrez Gene |
10327
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UniGene |
Hs.740781
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RefSeq |
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HUGO |
HGNC:380
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OMIM |
103830
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CCDS |
CCDS523
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HPRD |
00069
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IMGT |
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EMBL |
AF036680
AF036681
AF036682
AF036683
AF112484
AF112485
AK293083
AL355480
BC000670
BC005394
BT007003
CH471059
CR457010
EU668319
EU794588
J04794
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GenPept |
AAA51711
AAB92369
AAF01260
AAH00670
AAH05394
AAP35649
ACF94472
ACJ13642
BAF85772
CAG33291
CAI22459
EAX06970
EAX06971
EAX06972
EAX06974
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