InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NASP

Summary

InnateDB Protein

IDBP-97988.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NASP

Protein Name

nuclear autoantigenic sperm protein (histone-binding)

Synonyms

FLB7527; PRO1999;

Species

Homo sapiens

Ensembl Protein

ENSP00000255121

InnateDB Gene

IDBG-97982 (NASP)

Protein Structure

UniProt Annotation

Function

Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus.

Disease Associations

Tissue Specificity

Isoform 1 is testis- and sperm-specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	41 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0051879	Hsp90 protein binding

Biological Process

GO:0001824	blastocyst development
GO:0006260	DNA replication
GO:0006335	DNA replication-dependent nucleosome assembly
GO:0006336	DNA replication-independent nucleosome assembly
GO:0007049	cell cycle
GO:0008283	cell proliferation
GO:0015031	protein transport
GO:0043486	histone exchange

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR001440 Tetratricopeptide TPR1
IPR013026 Tetratricopeptide repeat-containing domain
IPR019544 Tetratricopeptide, SHNi-TPR domain
IPR019734 Tetratricopeptide repeat

PFAM

PF00515
PF10516
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P49321