Version 5.4
Homo sapiens Gene: NASP
Summary
InnateDB Gene IDBG-97982.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NASP
Gene Name nuclear autoantigenic sperm protein (histone-binding)
Synonyms FLB7527; PRO1999
Species Homo sapiens
Ensembl Gene ENSG00000132780
Encoded Proteins
IDBP-97986
nuclear autoantigenic sperm protein (histone-binding)
IDBP-97988
nuclear autoantigenic sperm protein (histone-binding)
IDBP-97990
nuclear autoantigenic sperm protein (histone-binding)
IDBP-383267
nuclear autoantigenic sperm protein (histone-binding)
IDBP-383280
nuclear autoantigenic sperm protein (histone-binding)
IDBP-383282
nuclear autoantigenic sperm protein (histone-binding)
IDBP-586027
nuclear autoantigenic sperm protein (histone-binding)
IDBP-601696
nuclear autoantigenic sperm protein (histone-binding)
IDBP-596646
nuclear autoantigenic sperm protein (histone-binding)
IDBP-589887
nuclear autoantigenic sperm protein (histone-binding)
IDBP-594980
nuclear autoantigenic sperm protein (histone-binding)
IDBP-602333
nuclear autoantigenic sperm protein (histone-binding)
IDBP-599752
nuclear autoantigenic sperm protein (histone-binding)
IDBP-588404
nuclear autoantigenic sperm protein (histone-binding)
IDBP-595687
nuclear autoantigenic sperm protein (histone-binding)
IDBP-600831
nuclear autoantigenic sperm protein (histone-binding)
IDBP-588077
nuclear autoantigenic sperm protein (histone-binding)
IDBP-583326
nuclear autoantigenic sperm protein (histone-binding)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:45583846-45618904
Strand Forward strand
Band p34.1
Transcripts
ENST00000350030 ENSP00000255120
ENST00000351223 ENSP00000255121
ENST00000372052 ENSP00000361122
ENST00000437901 ENSP00000400792
ENST00000453748 ENSP00000403157
ENST00000437362 ENSP00000388010
ENST00000470768 ENSP00000436924
ENST00000464190
ENST00000481782
ENST00000472408
ENST00000528084 ENSP00000435363
ENST00000527359 ENSP00000436790
ENST00000530840 ENSP00000435548
ENST00000531532 ENSP00000436778
ENST00000529333 ENSP00000436388
ENST00000527470 ENSP00000437241
ENST00000525515 ENSP00000436939
ENST00000528238 ENSP00000432289
ENST00000534101
ENST00000530073
ENST00000531612 ENSP00000437116
ENST00000527932
ENST00000534450 ENSP00000434240
ENST00000537798 ENSP00000438871
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 41 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042393 histone binding
GO:0051879 Hsp90 protein binding
Biological Process
GO:0001824 blastocyst development
GO:0006260 DNA replication
GO:0006335 DNA replication-dependent nucleosome assembly
GO:0006336 DNA replication-independent nucleosome assembly
GO:0007049 cell cycle
GO:0008283 cell proliferation
GO:0015031 protein transport
GO:0043486 histone exchange
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028693
View Gene Order
ENSBTAG00000015346
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001195193 NM_002482 NM_152298 XM_005270888
HUGO
OMIM
CCDS CCDS524 CCDS525 CCDS55597
HPRD 04423
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca