InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP4B1

Summary

InnateDB Protein

IDBP-98189.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP4B1

Protein Name

cytochrome P450, family 4, subfamily B, polypeptide 1

Synonyms

CYPIVB1; P-450HP;

Species

Homo sapiens

Ensembl Protein

ENSP00000360991

InnateDB Gene

IDBG-98187 (CYP4B1)

Protein Structure

UniProt Annotation

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Detected in the liver and lung (at protein level). {ECO:0000269PubMed:12695542}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0008144	drug binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0018585	fluorene oxygenase activity
GO:0019825	oxygen binding
GO:0020037	heme binding
GO:0070330	aromatase activity

Biological Process

GO:0006725	cellular aromatic compound metabolic process
GO:0006805	xenobiotic metabolic process
GO:0018879	biphenyl metabolic process
GO:0018917	fluorene metabolic process
GO:0042738	exogenous drug catabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002402 Cytochrome P450, E-class, group II
IPR002403 Cytochrome P450, E-class, group IV

PFAM

PF00067

PRINTS

PR00385
PR00463
PR00464
PR00465

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P13584