InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYP4B1

Summary

InnateDB Gene

IDBG-98187.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP4B1

Gene Name

cytochrome P450, family 4, subfamily B, polypeptide 1

Synonyms

CYPIVB1; P-450HP

Species

Homo sapiens

Ensembl Gene

ENSG00000142973

Encoded Proteins

IDBP-98189

cytochrome P450, family 4, subfamily B, polypeptide 1

IDBP-98191

cytochrome P450, family 4, subfamily B, polypeptide 1

IDBP-98193

cytochrome P450, family 4, subfamily B, polypeptide 1

IDBP-383614

cytochrome P450, family 4, subfamily B, polypeptide 1

IDBP-585318

cytochrome P450, family 4, subfamily B, polypeptide 1

IDBP-593177

cytochrome P450, family 4, subfamily B, polypeptide 1

IDBP-598543

cytochrome P450, family 4, subfamily B, polypeptide 1

IDBP-601526

cytochrome P450, family 4, subfamily B, polypeptide 1

IDBP-598487

cytochrome P450, family 4, subfamily B, polypeptide 1

IDBP-811199

cytochrome P450, family 4, subfamily B, polypeptide 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Two transcript variants encoding slightly different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:46757838-46819413

Strand

Forward strand

Band

p33

Transcripts

ENST00000371923	ENSP00000360991
ENST00000371919	ENSP00000360987
ENST00000271153	ENSP00000271153
ENST00000413093
ENST00000452782	ENSP00000400413
ENST00000464439	ENSP00000433068
ENST00000468637	ENSP00000437670
ENST00000481248
ENST00000497005
ENST00000546128
ENST00000534708	ENSP00000433367
ENST00000529715	ENSP00000443212
ENST00000526297	ENSP00000438995
ENST00000614163	ENSP00000484629

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0008144	drug binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0018585	fluorene oxygenase activity
GO:0019825	oxygen binding
GO:0020037	heme binding
GO:0070330	aromatase activity

Biological Process

GO:0006725	cellular aromatic compound metabolic process
GO:0006805	xenobiotic metabolic process
GO:0018879	biphenyl metabolic process
GO:0018917	fluorene metabolic process
GO:0042738	exogenous drug catabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process