InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CMPK1

Summary

InnateDB Protein

IDBP-98284.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CMPK1

Protein Name

cytidine monophosphate (UMP-CMP) kinase 1, cytosolic

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000360939

InnateDB Gene

IDBG-98280 (CMPK1)

Protein Structure

UniProt Annotation

Function

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000255HAMAP-Rule:MF_03172, ECO:0000269PubMed:10462544, ECO:0000269PubMed:11912132, ECO:0000269PubMed:23416111}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Predominantly nuclear.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:11681623}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004127	cytidylate kinase activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0004849	uridine kinase activity
GO:0005524	ATP binding
GO:0009041	uridylate kinase activity
GO:0016301	kinase activity
GO:0033862	UMP kinase activity

Biological Process

GO:0006165	nucleoside diphosphate phosphorylation
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221	pyrimidine nucleotide biosynthetic process
GO:0006222	UMP biosynthetic process
GO:0006225	UDP biosynthetic process
GO:0006227	dUDP biosynthetic process
GO:0006240	dCDP biosynthetic process
GO:0009142	nucleoside triphosphate biosynthetic process
GO:0009220	pyrimidine ribonucleotide biosynthetic process
GO:0015949	nucleobase-containing small molecule interconversion
GO:0018963	phthalate metabolic process
GO:0022602	ovulation cycle process
GO:0044281	small molecule metabolic process
GO:0046705	CDP biosynthetic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000850 Adenylate kinase/UMP-CMP kinase
IPR006266 UMP-CMP kinase
IPR010488 Zeta toxin domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF06414

PRINTS

PR00094

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P30085