InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDKN2C

Summary

InnateDB Protein

IDBP-98427.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDKN2C

Protein Name

cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

Synonyms

INK4C; p18; p18-INK4C;

Species

Homo sapiens

Ensembl Protein

ENSP00000360826

InnateDB Gene

IDBG-98423 (CDKN2C)

Protein Structure

UniProt Annotation

Function

Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.

Subcellular Localization

Disease Associations

Tissue Specificity

Highest levels found in skeletal muscle. Also found in pancreas and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0030308	negative regulation of cell growth
GO:0042326	negative regulation of phosphorylation
GO:0071901	negative regulation of protein serine/threonine kinase activity