InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDKN2C

Summary

InnateDB Gene

IDBG-98423.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDKN2C

Gene Name

cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

Synonyms

INK4C; p18; p18-INK4C

Species

Homo sapiens

Ensembl Gene

ENSG00000123080

Encoded Proteins

IDBP-98425

cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

IDBP-98427

cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

IDBP-238124

cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:50960745-50974633

Strand

Forward strand

Band

p32.3

Transcripts

ENST00000262662	ENSP00000262662
ENST00000371761	ENSP00000360826
ENST00000396148	ENSP00000379452

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0030308	negative regulation of cell growth
GO:0042326	negative regulation of phosphorylation
GO:0048709	oligodendrocyte differentiation
GO:0071901	negative regulation of protein serine/threonine kinase activity