InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EPS15

Summary

InnateDB Protein

IDBP-98486.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPS15

Protein Name

epidermal growth factor receptor pathway substrate 15

Synonyms

AF-1P; AF1P; MLLT5;

Species

Homo sapiens

Ensembl Protein

ENSP00000360798

InnateDB Gene

IDBG-98484 (EPS15)

Protein Structure

UniProt Annotation

Function

Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269PubMed:16903783, ECO:0000269PubMed:18362181, ECO:0000269PubMed:19458185, ECO:0000269PubMed:22648170}.

Subcellular Localization

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Recruited to the plasma membrane upon EGFR activation and localizes to coated pits.Isoform 2: Early endosome membrane {ECO:0000269PubMed:18362181}; Peripheral membrane protein {ECO:0000269PubMed:18362181}; Cytoplasmic side {ECO:0000269PubMed:18362181}. Note=Colocalizes with HGS on bilayered clathrin coats on endosomes.

Disease Associations

Note=A chromosomal aberration involving EPS15 is found in acute leukemias. Translocation t(1;11)(p32;q23) with KMT2A/MLL1. The result is a rogue activator protein.

Tissue Specificity

Ubiquitously expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 151 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	151 [view]
Protein-Protein	150 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0031593	polyubiquitin binding
GO:0042802	identical protein binding

Biological Process

GO:0006895	Golgi to endosome transport
GO:0006897	endocytosis
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008283	cell proliferation
GO:0015031	protein transport
GO:0016050	vesicle organization
GO:0032456	endocytic recycling
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0048268	clathrin coat assembly

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0016020	membrane
GO:0030122	AP-2 adaptor complex
GO:0030132	clathrin coat of coated pit
GO:0030136	clathrin-coated vesicle
GO:0031901	early endosome membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0060170	ciliary membrane