Version 5.4
Homo sapiens Protein: NRD1
Summary
InnateDB Protein IDBP-98547.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NRD1
Protein Name nardilysin (N-arginine dibasic convertase)
Synonyms hNRD1; hNRD2;
Species Homo sapiens
Ensembl Protein ENSP00000262679
InnateDB Gene IDBG-98541 (NRD1)
Protein Structure
UniProt Annotation
Function Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.
Subcellular Localization
Disease Associations
Tissue Specificity Primarily in adult heart, skeletal muscle, and testis and at much lower levels in other tissues.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
Experimentally validated
Total 45 [view]
Protein-Protein 42 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0048408 epidermal growth factor binding
Biological Process
GO:0006508 proteolysis
GO:0007528 neuromuscular junction development
GO:0008283 cell proliferation
GO:0016477 cell migration
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0052548 regulation of endopeptidase activity
Cellular Component
GO:0005829 cytosol
GO:0009986 cell surface
Protein Structure and Domains
PDB ID
InterPro IPR007863 Peptidase M16, C-terminal domain
IPR011249 Metalloenzyme, LuxS/M16 peptidase-like
IPR011765 Peptidase M16, N-terminal
PFAM PF05193
PF00675
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43847
PhosphoSite PhosphoSite-O43847
TrEMBL B4DRI0
UniProt Splice Variant
Entrez Gene 4898
UniGene Hs.584782
RefSeq NP_001095132
HUGO HGNC:7995
OMIM 602651
CCDS CCDS41335
HPRD 04036
IMGT
EMBL AJ000350 AK299271 AL050343 AL589663 BC008775 CH471059 U64898 X93207 X93209
GenPept AAC39597 AAH08775 BAG61292 CAA04025 CAA63694 CAA63698 CAH74100 CAI22216 EAX06809

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca