Version 5.4
Homo sapiens Gene: NRD1
Summary
InnateDB Gene IDBG-98541.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NRD1
Gene Name nardilysin (N-arginine dibasic convertase)
Synonyms hNRD1; hNRD2
Species Homo sapiens
Ensembl Gene ENSG00000078618
Encoded Proteins
IDBP-98543
nardilysin (N-arginine dibasic convertase)
IDBP-98547
nardilysin (N-arginine dibasic convertase)
IDBP-384167
nardilysin (N-arginine dibasic convertase)
IDBP-586714
nardilysin (N-arginine dibasic convertase)
IDBP-600929
nardilysin (N-arginine dibasic convertase)
IDBP-813407
nardilysin (N-arginine dibasic convertase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:51789191-51878937
Strand Reverse strand
Band p32.3
Transcripts
ENST00000354831 ENSP00000346890
ENST00000352171 ENSP00000262679
ENST00000440943 ENSP00000398464
ENST00000485608
ENST00000464385
ENST00000497358
ENST00000475310
ENST00000483007
ENST00000473805
ENST00000475715
ENST00000491410
ENST00000468722
ENST00000539524 ENSP00000444416
ENST00000544028 ENSP00000442262
ENST00000615102 ENSP00000481902
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
Experimentally validated
Total 45 [view]
Protein-Protein 42 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0048408 epidermal growth factor binding
Biological Process
GO:0006508 proteolysis
GO:0007528 neuromuscular junction development
GO:0008283 cell proliferation
GO:0016477 cell migration
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0052548 regulation of endopeptidase activity
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0009986 cell surface
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000053510
View Gene Order
ENSBTAG00000021174
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 4898
UniGene Hs.584782
RefSeq NM_001101662 NM_001242361 NM_002525 XM_005270903
HUGO HGNC:7995
OMIM 602651
CCDS CCDS41335 CCDS55599 CCDS559
HPRD 04036
IMGT
EMBL
GenPept
RNA Seq Atlas 4898

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca