InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC22A2

Summary

InnateDB Protein

IDBP-98689.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC22A2

Protein Name

solute carrier family 22 (organic cation transporter), member 2

Synonyms

OCT2;

Species

Homo sapiens

Ensembl Protein

ENSP00000355920

InnateDB Gene

IDBG-98687 (SLC22A2)

Protein Structure

UniProt Annotation

Function

Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity. {ECO:0000269PubMed:12089365, ECO:0000269PubMed:12538837, ECO:0000269PubMed:15496291, ECO:0000269PubMed:15783073, ECO:0000269PubMed:16006492, ECO:0000269PubMed:16272756, ECO:0000269PubMed:16314463, ECO:0000269PubMed:16394027, ECO:0000269PubMed:16914559, ECO:0000269PubMed:16951202, ECO:0000269PubMed:17072098, ECO:0000269PubMed:17582384, ECO:0000269PubMed:9260930, ECO:0000269PubMed:9687576}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Mainly expressed in kidney. Localized at the luminal membrane and basolateral membrane of kidney distal tubule and proximal tubules. To a lower extent, expressed in neurons of the cerebral cortex and in various subcortical nuclei (at protein levels). Also detected in secretory phase endometrium; in scattered cells in the stroma. {ECO:0000269PubMed:11912245, ECO:0000269PubMed:17393420, ECO:0000269PubMed:9260930, ECO:0000269PubMed:9687576}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005496	steroid binding
GO:0015075	ion transmembrane transporter activity
GO:0015101	organic cation transmembrane transporter activity
GO:0015220	choline transmembrane transporter activity
GO:0015651	quaternary ammonium group transmembrane transporter activity
GO:0022857	transmembrane transporter activity

Biological Process

GO:0006812	cation transport
GO:0006855	drug transmembrane transport
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0007589	body fluid secretion
GO:0015695	organic cation transport
GO:0015697	quaternary ammonium group transport
GO:0015871	choline transport
GO:0034220	ion transmembrane transport
GO:0042136	neurotransmitter biosynthetic process
GO:0044281	small molecule metabolic process
GO:0051608	histamine transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR004749 Organic cation transport protein
IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00083
PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O15244

PhosphoSite