InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC22A2

Summary

InnateDB Gene

IDBG-98687.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC22A2

Gene Name

solute carrier family 22 (organic cation transporter), member 2

Synonyms

OCT2

Species

Homo sapiens

Ensembl Gene

ENSG00000112499

Encoded Proteins

IDBP-98689

solute carrier family 22 (organic cation transporter), member 2

IDBP-98691

solute carrier family 22 (organic cation transporter), member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:160171061-160277638

Strand

Reverse strand

Band

q25.3

Transcripts

ENST00000366953	ENSP00000355920
ENST00000366952	ENSP00000355919
ENST00000486916
ENST00000498556
ENST00000491092
ENST00000489644

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005496	steroid binding
GO:0015075	ion transmembrane transporter activity
GO:0015101	organic cation transmembrane transporter activity
GO:0015220	choline transmembrane transporter activity
GO:0015651	quaternary ammonium group transmembrane transporter activity
GO:0022857	transmembrane transporter activity

Biological Process

GO:0006812	cation transport
GO:0006855	drug transmembrane transport
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0007589	body fluid secretion
GO:0015695	organic cation transport
GO:0015697	quaternary ammonium group transport
GO:0015871	choline transport
GO:0034220	ion transmembrane transport
GO:0042136	neurotransmitter biosynthetic process
GO:0044281	small molecule metabolic process
GO:0051608	histamine transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0070062	extracellular vesicular exosome