InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GLIS1

Summary

InnateDB Protein

IDBP-98759.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLIS1

Protein Name

GLIS family zinc finger 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000309653

InnateDB Gene

IDBG-98757 (GLIS1)

Protein Structure

UniProt Annotation

Function

Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). {ECO:0000250UniProtKB:Q8K1M4}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter