Version 5.4
Homo sapiens Protein: DIO1
Summary
InnateDB Protein IDBP-98809.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DIO1
Protein Name deiodinase, iodothyronine, type I
Synonyms 5DI; TXDI1;
Species Homo sapiens
Ensembl Protein ENSP00000323198
InnateDB Gene IDBG-98807 (DIO1)
Protein Structure
UniProt Annotation
Function Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004800 thyroxine 5'-deiodinase activity
Biological Process
GO:0006590 thyroid hormone generation
GO:0034641 cellular nitrogen compound metabolic process
GO:0042446 hormone biosynthetic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000643 Iodothyronine deiodinase
IPR012336 Thioredoxin-like fold
PFAM PF00837
PF13098
PF13192
PF13462
PF13905
PRINTS
PIRSF PIRSF001330
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P49895
PhosphoSite PhosphoSite-P49895
TrEMBL A8K415
UniProt Splice Variant
Entrez Gene 1733
UniGene Hs.251415
RefSeq NP_001034805
HUGO HGNC:2883
OMIM 147892
CCDS CCDS41340
HPRD 01002
IMGT
EMBL AK290780 AL031427 AY560374 AY560375 AY560376 AY560377 AY560378 AY560379 AY560380 AY560381 AY560382 AY560383 BC017955 BC107170 BC107171 CH471059 S48220 S79349
GenPept AAB23670 AAB35380 AAH17955 AAI07171 AAI07172 AAT02480 AAT02481 AAT02482 AAT02483 AAT02484 AAT02485 AAT02486 AAT02487 AAT02488 AAT02489 BAF83469 EAX06721

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca