Version 5.4
Homo sapiens Protein: QKI
Summary
InnateDB Protein IDBP-98874.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol QKI
Protein Name QKI, KH domain containing, RNA binding
Synonyms Hqk; hqkI; QK; QK1; QK3;
Species Homo sapiens
Ensembl Protein ENSP00000275262
InnateDB Gene IDBG-98868 (QKI)
Protein Structure
UniProt Annotation
Function RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients. {ECO:0000269PubMed:16342280}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 67 [view]
Protein-Protein 67 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0006417 regulation of translation
GO:0008380 RNA splicing
GO:0051028 mRNA transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR004087 K Homology domain
IPR004088 K Homology domain, type 1
PFAM PF00013
PF13014
PRINTS
PIRSF
SMART SM00322
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96PU8
PhosphoSite PhosphoSite-Q96PU8
TrEMBL F5H8C8
UniProt Splice Variant
Entrez Gene 9444
UniGene Hs.708585
RefSeq NP_996736
HUGO HGNC:21100
OMIM 609590
CCDS CCDS5287
HPRD 06691
IMGT
EMBL AB067798 AB067799 AB067800 AB067801 AB067808 AF142417 AF142418 AF142419 AF142420 AF142421 AF142422 AK027309 AK295235 AL031781 AL356119 AY780788 BC012222 BC019917 DQ323998
GenPept AAF63412 AAF63413 AAF63414 AAF63415 AAF63416 AAF63417 AAH12222 AAH19917 AAV98358 ABC88600 BAB55032 BAB69496 BAB69497 BAB69498 BAB69499 BAB69681 BAG58228 CAI21651 CAI21652 CAI21653 CAI23022 CAI23023 CAI23024

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca