Version 5.4
Homo sapiens Protein: ACOT11
Summary
InnateDB Protein IDBP-99002.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACOT11
Protein Name acyl-CoA thioesterase 11
Synonyms BFIT; STARD14; THEA; THEM1;
Species Homo sapiens
Ensembl Protein ENSP00000360366
InnateDB Gene IDBG-99000 (ACOT11)
Protein Structure
UniProt Annotation
Function Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity Isoform 1 is predominantly expressed in skeletal muscle, liver, testis, stomach, spleen, lung and brain. Isoform 2 is predominantly expressed in kidney, uterus, hibernoma and white adipose tissue.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008289 lipid binding
GO:0047617 acyl-CoA hydrolase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0009266 response to temperature stimulus
GO:0009409 response to cold
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002913 START domain
IPR006683 Thioesterase superfamily
IPR029069 HotDog domain
PFAM PF01852
PF03061
PRINTS
PIRSF
SMART SM00234
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WXI4
PhosphoSite PhosphoSite-Q8WXI4
TrEMBL
UniProt Splice Variant
Entrez Gene 26027
UniGene Hs.234786
RefSeq NP_056362
HUGO HGNC:18156
OMIM 606803
CCDS CCDS592
HPRD 07075
IMGT
EMBL AB014607 AC099796 AF416921 AF416922 AK023937 AK223570 AL590093 BC001517 BC093844 BC093846 CH471059
GenPept AAH01517 AAH93844 AAH93846 AAL40937 AAL40938 BAA31682 BAB14734 BAD97290 CAH71611 CAH71612 EAX06682 EAX06683 EAX06684

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca