Version 5.4
Homo sapiens Gene: ACOT11
Summary
InnateDB Gene IDBG-99000.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACOT11
Gene Name acyl-CoA thioesterase 11
Synonyms BFIT; STARD14; THEA; THEM1
Species Homo sapiens
Ensembl Gene ENSG00000162390
Encoded Proteins
IDBP-99002
acyl-CoA thioesterase 11
IDBP-99004
acyl-CoA thioesterase 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:54542257-54639192
Strand Forward strand
Band p32.3
Transcripts
ENST00000371316 ENSP00000360366
ENST00000343744 ENSP00000340260
ENST00000481208
ENST00000498228
ENST00000479837
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008289 lipid binding
GO:0047617 acyl-CoA hydrolase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0009266 response to temperature stimulus
GO:0009409 response to cold
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034853
View Gene Order
ENSBTAG00000039686
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.234786
RefSeq NM_015547 NM_147161
HUGO
OMIM
CCDS CCDS592 CCDS593
HPRD 07075
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca