Version 5.4
Homo sapiens Protein: CCR6
Summary
InnateDB Protein IDBP-99025.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCR6
Protein Name chemokine (C-C motif) receptor 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000339393
InnateDB Gene IDBG-99015 (CCR6)
Protein Structure
UniProt Annotation
Function Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level. {ECO:0000269PubMed:9169459}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004950 chemokine receptor activity
GO:0016493 C-C chemokine receptor activity
Biological Process
GO:0002407 dendritic cell chemotaxis
GO:0006928 cellular component movement
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0006959 humoral immune response
GO:0006968 cellular defense response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0045087 innate immune response (InnateDB)
GO:0070098 chemokine-mediated signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000174 CXC chemokine receptor 1/2
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR001277 CXC chemokine receptor 4
IPR004067 CC chemokine receptor 6
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00427
PR00237
PR00657
PR00645
PR01529
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P51684
PhosphoSite PhosphoSite-P51684
TrEMBL
UniProt Splice Variant
Entrez Gene 1235
UniGene Hs.46468
RefSeq
HUGO HGNC:1607
OMIM 601835
CCDS CCDS5298
HPRD 03498
IMGT
EMBL AL121935 AY242126 BC037960 CH471051 U45984 U60000 U68030 U68032 Z79784
GenPept AAB06949 AAB62714 AAC51124 AAC51125 AAH37960 AAO92293 CAB02144 CAB99328 EAW47506 EAW47507

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca