InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TCF20

Summary

InnateDB Protein

IDBP-9907.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TCF20

Protein Name

transcription factor 20 (AR1)

Synonyms

AR1; SPBP; TCF-20;

Species

Homo sapiens

Ensembl Protein

ENSP00000352463

InnateDB Gene

IDBG-9905 (TCF20)

Protein Structure

UniProt Annotation

Function

Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in most tissues, except in ovary and prostate. Isoform 1 is exclusively expressed in brain, heart and testis, and this form predominates in liver and kidney. Isoform 2 predominates in lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding