Version 5.4
Homo sapiens Gene: TCF20
Summary
InnateDB Gene IDBG-9905.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCF20
Gene Name transcription factor 20 (AR1)
Synonyms AR1; SPBP; TCF-20
Species Homo sapiens
Ensembl Gene ENSG00000100207
Encoded Proteins
IDBP-9907
transcription factor 20 (AR1)
IDBP-9909
transcription factor 20 (AR1)
IDBP-293120
transcription factor 20 (AR1)
IDBP-719957
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene binds a platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 (stromelysin 1) promoter. The protein localizes to the nucleus and displays DNA-binding and transactivation activities. It is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a transcription factor that recognizes the platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 promoter. The encoded protein is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:42160013-42343616
Strand Reverse strand
Band q13.2
Transcripts
ENST00000359486 ENSP00000352463
ENST00000335626 ENSP00000335561
ENST00000404876 ENSP00000385531
ENST00000515426 ENSP00000458948
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041852
View Gene Order
ENSBTAG00000000662
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.475018 Hs.600949 Hs.614174
RefSeq NM_005650 NM_181492 XM_005261722 XM_005261723 XM_005261724 XM_005276955 XM_005276956 XM_005276957 XM_006724313 XM_006724314 XM_006725781 XM_006725782 XM_006725783
HUGO
OMIM
CCDS CCDS14032 CCDS14033
HPRD 04378
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca