InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPAP2B

Summary

InnateDB Protein

IDBP-99135.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPAP2B

Protein Name

phosphatidic acid phosphatase type 2B

Synonyms

Dri42; LPP3; PAP2B; VCIP;

Species

Homo sapiens

Ensembl Protein

ENSP00000360296

InnateDB Gene

IDBG-99131 (PPAP2B)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.

Subcellular Localization

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Highly expressed in heart and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	8 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004721	phosphoprotein phosphatase activity
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008195	phosphatidate phosphatase activity
GO:0042392	sphingosine-1-phosphate phosphatase activity
GO:0042577	lipid phosphatase activity

Biological Process

GO:0001568	blood vessel development
GO:0001702	gastrulation with mouth forming second
GO:0001933	negative regulation of protein phosphorylation
GO:0006629	lipid metabolic process
GO:0006644	phospholipid metabolic process
GO:0006665	sphingolipid metabolic process
GO:0007155	cell adhesion
GO:0008354	germ cell migration
GO:0016311	dephosphorylation
GO:0016337	single organismal cell-cell adhesion
GO:0030111	regulation of Wnt signaling pathway
GO:0030148	sphingolipid biosynthetic process
GO:0034109	homotypic cell-cell adhesion
GO:0044281	small molecule metabolic process
GO:0044328	canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration
GO:0044329	canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion
GO:0044330	canonical Wnt signaling pathway involved in positive regulation of wound healing
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050821	protein stabilization
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060020	Bergmann glial cell differentiation
GO:0060070	canonical Wnt signaling pathway
GO:1902068	regulation of sphingolipid mediated signaling pathway

Cellular Component

GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005912	adherens junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome