InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: C8A

Summary

InnateDB Protein

IDBP-99148.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C8A

Protein Name

complement component 8, alpha polypeptide

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000354458

InnateDB Gene

IDBG-99144 (C8A)

Protein Structure

UniProt Annotation

Function

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself. {ECO:0000269PubMed:17872444, ECO:0000269PubMed:7440581}.

Subcellular Localization

Secreted. Cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein. Inserts into the cell membrane of target cells.

Disease Associations

Complement component 8 deficiency, 1 (C8D1) [MIM:613790]: A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001848	complement binding
GO:0005515	protein binding
GO:0032403	protein complex binding

Biological Process

GO:0006955	immune response
GO:0006956	complement activation
GO:0006957	complement activation, alternative pathway
GO:0006958	complement activation, classical pathway
GO:0019835	cytolysis
GO:0030449	regulation of complement activation
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005576	extracellular region
GO:0005579	membrane attack complex
GO:0005615	extracellular space
GO:0016020	membrane
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

InterPro

IPR000884 Thrombospondin, type 1 repeat
IPR001862 Membrane attack complex component/perforin/complement C9
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR020864 Membrane attack complex component/perforin (MACPF) domain

PFAM

PF00090
PF00057
PF01823

PRINTS

PR00764
PR00261

PIRSF

SMART

SM00209
SM00192
SM00457

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt