Version 5.4
Homo sapiens Gene: C8A
Summary
InnateDB Gene IDBG-99144.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C8A
Gene Name complement component 8, alpha polypeptide
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000157131
Encoded Proteins
IDBP-99148
complement component 8, alpha polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 12220191
C8A is the alpha subunit of complement factor 8 (C8) and is one of five components that interact to form the cytolytic membrane attack complex (MAC).
Entrez Gene
Summary C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency. [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:56854806-56918221
Strand Forward strand
Band p32.2
Transcripts
ENST00000361249 ENSP00000354458
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001848 complement binding
GO:0005515 protein binding
GO:0032403 protein complex binding
Biological Process
GO:0006955 immune response
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0019835 cytolysis
GO:0030449 regulation of complement activation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0005615 extracellular space
GO:0016020 membrane
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035031
View Gene Order
ENSBTAG00000003774
Not yet available
Pathways
NETPATH
REACTOME
REACT_8028
Terminal pathway of complement pathway
REACT_118707
Regulation of Complement cascade pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_6932
Complement cascade pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
hsa05322
Systemic lupus erythematosus pathway
hsa05020
Prion diseases pathway
hsa05146
Amoebiasis pathway
INOH
PID NCI
Cross-References
SwissProt P07357
TrEMBL
UniProt Splice Variant
Entrez Gene 731
UniGene Hs.93210
RefSeq NM_000562
HUGO HGNC:1352
OMIM 120950
CCDS CCDS606
HPRD
IMGT
EMBL AL121998 BC132911 BC132913 M16974 U07996 U07997 U07998 U07999 U08000 U08001 U08002 U08003 U08004 U08005 U08006
GenPept AAA52200 AAA82124 AAI32912 AAI32914 CAI19172
RNA Seq Atlas 731

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca