InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: C8B

Summary

InnateDB Protein

IDBP-99159.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C8B

Protein Name

complement component 8, beta polypeptide

Synonyms

C82;

Species

Homo sapiens

Ensembl Protein

ENSP00000360281

InnateDB Gene

IDBG-99157 (C8B)

Protein Structure

UniProt Annotation

Function

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.

Subcellular Localization

Secreted.

Disease Associations

Complement component 8 deficiency, 2 (C8D2) [MIM:613789]: A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	2 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032403	protein complex binding

Biological Process

GO:0006955	immune response
GO:0006956	complement activation
GO:0006957	complement activation, alternative pathway
GO:0006958	complement activation, classical pathway
GO:0019835	cytolysis
GO:0030449	regulation of complement activation
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005576	extracellular region
GO:0005579	membrane attack complex
GO:0005615	extracellular space
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000884 Thrombospondin, type 1 repeat
IPR001862 Membrane attack complex component/perforin/complement C9
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR020864 Membrane attack complex component/perforin (MACPF) domain

PFAM

PF00090
PF00057
PF01823

PRINTS

PR00764
PR00261

PIRSF

SMART

SM00209
SM00192
SM00457

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt