InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DACT2

Summary

InnateDB Protein

IDBP-99195.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DACT2

Protein Name

dapper, antagonist of beta-catenin, homolog 2 (Xenopus laevis)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000355761

InnateDB Gene

IDBG-99193 (DACT2)

Protein Structure

UniProt Annotation

Function

Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0008013	beta-catenin binding
GO:0008134	transcription factor binding
GO:0051018	protein kinase A binding
GO:0070097	delta-catenin binding

Biological Process

GO:0003382	epithelial cell morphogenesis
GO:0007162	negative regulation of cell adhesion
GO:0043588	skin development
GO:0072061	inner medullary collecting duct development
GO:1900108	negative regulation of nodal signaling pathway