Version 5.4
Homo sapiens Protein: SMOC2
Summary
InnateDB Protein IDBP-99200.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMOC2
Protein Name SPARC related modular calcium binding 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000346537
InnateDB Gene IDBG-99198 (SMOC2)
Protein Structure
UniProt Annotation
Function Promotes matrix assembly and cell adhesiveness (By similarity). Can stimulate endothelial cell proliferation, migration, as well as angiogenesis. {ECO:0000250, ECO:0000269PubMed:16774925}.
Subcellular Localization Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}.
Disease Associations Dentin dysplasia 1 (DTDP1) [MIM:125400]: A dental defect in which both primary and secondary dentitions are affected. The clinical crowns of both permanent and deciduous teeth are of normal shape, form and color in most cases, although they may be slightly opalescent and blue or brown. Teeth may be very mobile and exfoliate spontaneously because of inadequate root formation. On radiographs, the roots are short and may be more pointed than normal. Pulp chambers are usually absent except for a chevron- shaped remnant in the crown. Root canals are usually absent. {ECO:0000269PubMed:22152679}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005539 glycosaminoglycan binding
GO:0008201 heparin binding
Biological Process
GO:0007165 signal transduction
GO:0010811 positive regulation of cell-substrate adhesion
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005604 basement membrane
GO:0005614 interstitial matrix
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID
InterPro IPR000716 Thyroglobulin type-1
IPR002048 EF-hand domain
IPR002350 Kazal domain
IPR019577 SPARC/Testican, calcium-binding domain
PFAM PF00086
PF00036
PF13202
PF13405
PF00050
PF07648
PF10591
PRINTS
PIRSF
SMART SM00211
SM00054
SM00280
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H3U7
PhosphoSite PhosphoSite-Q9H3U7
TrEMBL B4DNB1
UniProt Splice Variant
Entrez Gene 64094
UniGene Hs.487200
RefSeq NP_071421
HUGO HGNC:20323
OMIM 607223
CCDS CCDS5307
HPRD 06244
IMGT
EMBL AB014730 AB014737 AF173892 AJ249902 AK056700 AK297839 AK315920 AL109940 AL136099 AL138918 AL442124 AL832303 BC028420 BC047583 CH471051
GenPept AAH28420 AAH47583 AAQ13639 BAB20267 BAB20274 BAG51789 BAG60173 BAH14291 CAC10353 CAI20434 CAI20435 CAI46175 EAW47462

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca