Version 5.4
Homo sapiens Gene: SMOC2
Summary
InnateDB Gene IDBG-99198.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMOC2
Gene Name SPARC related modular calcium binding 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000112562
Encoded Proteins
IDBP-99200
SPARC related modular calcium binding 2
IDBP-99202
SPARC related modular calcium binding 2
IDBP-246348
SPARC related modular calcium binding 2
IDBP-388323
SPARC related modular calcium binding 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:168441151-168673445
Strand Forward strand
Band q27
Transcripts
ENST00000354536 ENSP00000346537
ENST00000356284 ENSP00000348630
ENST00000392100 ENSP00000375949
ENST00000417208 ENSP00000398696
ENST00000477998
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005539 glycosaminoglycan binding
GO:0008201 heparin binding
Biological Process
GO:0007165 signal transduction
GO:0010811 positive regulation of cell-substrate adhesion
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005604 basement membrane
GO:0005614 interstitial matrix
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023886
View Gene Order
ENSBTAG00000013176
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.487200
RefSeq NM_001166412 NM_022138
HUGO
OMIM
CCDS CCDS5307 CCDS55076
HPRD 06244
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca