InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TACSTD2

Summary

InnateDB Protein

IDBP-99212.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TACSTD2

Protein Name

tumor-associated calcium signal transducer 2

Synonyms

EGP-1; EGP1; GA733-1; GA7331; GP50; M1S1; TROP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000360269

InnateDB Gene

IDBG-99210 (TACSTD2)

Protein Structure

UniProt Annotation

Function

May function as a growth factor receptor.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Corneal dystrophy, gelatinous drop-like (GDLD) [MIM:204870]: A form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. GDLD is an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clinical manifestations, which appear in the first decade of life, include blurred vision, photophobia, and foreign-body sensation. By the third decade, raised, yellowish- gray, gelatinous masses severely impair visual acuity. {ECO:0000269PubMed:10192395}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Placenta, pancreatic carcinoma cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007601	visual perception
GO:0008283	cell proliferation
GO:0010633	negative regulation of epithelial cell migration
GO:0050678	regulation of epithelial cell proliferation
GO:0051497	negative regulation of stress fiber assembly
GO:0060675	ureteric bud morphogenesis
GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis
GO:1900025	negative regulation of substrate adhesion-dependent cell spreading
GO:1900028	negative regulation of ruffle assembly
GO:2000146	negative regulation of cell motility
GO:2000738	positive regulation of stem cell differentiation

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009925	basal plasma membrane
GO:0016020	membrane
GO:0016328	lateral plasma membrane
GO:0070062	extracellular vesicular exosome